Open Compound Sourcing*

Share your compounds to be tested on our screening platforms as a first long-term collaboration step.


 

* This program is not open to U.S. healthcare professionals.

Boost the therapeutic potential of your compounds

Through our Open Compound Sourcing initiative, we invite potential partners to submit their compounds to be included in our high throughput screening library and utilized in efforts to identify new therapeutics.

We’re looking for new organic chemical compounds to test in our screening campaigns for potential therapeutic activity. Your compounds would be tested against several targets and disease models. In case of a match, your specific compounds could become the next new chemical entity (NCE) or a starting point for further optimization in one of our strategic therapeutic areas of focus: Oncology, Immuno-Oncology as well as Autoimmune Disorders. You will keep all rights to your compounds and in case of interest, we will offer you a follow-up collaboration agreement.

Who can apply?

Merck KGaA, Darmstadt, Germany, invites universities, research institutes and private companies to register with us to participate in the Open Compound Sourcing Initiative. After registration, participants will sign a “Participation and Material Supply Agreement (P&MSA)”. The agreement will cover the legal, intellectual property and commercial aspects of transferring your organic compounds to Merck KGaA, Darmstadt, Germany.

This program is not open to U.S. healthcare professionals.

 

How does it work?

After having a P&MSA in place, we screen your compounds in-silico. We therefore need the compound structure as SD-file (find more information about the SD file format in our FAQs). In a second step, we will ask you to provide the compounds selected based on the in-silico
screen. These compounds would then be included in the screening library for pharmaceutical activity testing. In case of hits, we will contact you to discuss the potential follow-up collaboration.       

Your benefits

For each compound accepted for inclusion in our screening library, participants will receive €100 per compound.

If a compound qualifies as a hit during our screening campaigns, participants will be further compensated according to the terms of the P&MSA. At that time, participants will be contacted about partnership opportunities.

By participating in our Open Compound Sourcing, your molecule could become a much-needed therapy, helping to transform the lives of patients with serious unmet medical needs, or a promising starting point for further chemical optimization to achieve that goal.

How to apply

Please contact us to request the P&MSA document. You will then be asked to fill out and submit the P&MSA document via e-mail. We will then review the document and contact you regarding next steps for compound provision. Before registering, please read the FAQ below.

 

FAQs

How can I participate in the Open Compound Sourcing program?

How can I participate in the Open Compound Sourcing program?

Can I participate in the program as a private individual?

Can I participate in the program as a private individual?

Can the P&MSA be amended or adapted to the requirements of my institution?

Can the P&MSA be amended or adapted to the requirements of my institution?

How do I provide the compound structures for your initial evaluation?

How do I provide the compound structures for your initial evaluation?

How do I generate and submit a Structure Data (SD) file?

How do I generate and submit a Structure Data (SD) file?

Where can I find free software for generating SD files?

Where can I find free software for generating SD files?

Are there guidelines for drawing and transferring the chemical structures to a SD file?

Are there guidelines for drawing and transferring the chemical structures to a SD file?

Is additional data required for submission, and in which file format?

Is additional data required for submission, and in which file format?

What happens to the data in the SD file after I have submitted the file?

What happens to the data in the SD file after I have submitted the file?

What are the requirements to be eligible for submission?

What are the requirements to be eligible for submission?

How are the submitted structures handled after submission?

How are the submitted structures handled after submission?

How do I ship the compounds to Merck KGaA, Darmstadt, Germany?

How do I ship the compounds to Merck KGaA, Darmstadt, Germany?

What is the turn-around time following submission of my compound structures?

What is the turn-around time following submission of my compound structures?

Can I obtain the biological data generated with my compounds?

Can I obtain the biological data generated with my compounds?

What happens if my compounds are active in your screening campaigns?

What happens if my compounds are active in your screening campaigns?

Can I use my own vials? Can I send compounds directly to Merck KGaA, Darmstadt, Germany?

Can I use my own vials? Can I send compounds directly to Merck KGaA, Darmstadt, Germany?

How much of the compound(s) do I have to provide you with?

How much of the compound(s) do I have to provide you with?

What happens to my compound(s) after physically shipping them to you, if they do not pass

What happens to my compound(s) after physically shipping them to you, if they do not pass

Boost the therapeutic potential of your compounds

Through our Open Compound Sourcing initiative, we invite potential partners to submit their compounds to be included in our high throughput screening library and utilized in efforts to identify new therapeutics.

We’re looking for new organic chemical compounds to test in our screening campaigns for potential therapeutic activity. Your compounds would be tested against several targets and disease models. In case of a match, your specific compounds could become the next new chemical entity (NCE) or a starting point for further optimization in one of our strategic therapeutic areas of focus: Oncology,and Immuno-Oncology as well as Autoimmune Disorders.. You will keep all rights to your compounds and in case of interest, we will offer you a follow-up collaboration agreement.

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